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Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
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Anaphylaxis to drug excipients.
1Allergy Center Hessen, Department of Dermatology and Allergology, University Hospital Marburg, Philipps-Universität Marburg, Baldinger Straße, 35043 Marburg, Germany.
Allergo Journal International
|June 7, 2022
Summary
Anaphylaxis to drug excipients is an underestimated issue. Recognizing and diagnosing these reactions is crucial for patient safety, despite diagnostic challenges.
Area of Science:
- Allergy and Immunology
- Pharmacology
- Drug Safety
Background:
- Drugs contain excipients (stabilizers, preservatives, dyes) that can also be food additives.
- Anaphylaxis to drug excipients is an underrecognized problem, with increasing case reports over 30 years.
- A diagnostic gap exists when the causative drug or excipient is unknown or unavailable for testing.
Purpose of the Study:
- To highlight anaphylaxis to specific drug excipients with available literature.
- To discuss current in vivo and in vitro allergological testing options.
- To present current concepts on the pathogenesis of excipient-induced anaphylaxis.
Main Methods:
- Review of publications on anaphylaxis to individual drug excipients.
- Discussion of diagnostic approaches for drug excipient allergies.
- Overview of current pathogenetic concepts.
Main Results:
- Identified specific excipients linked to anaphylaxis reports.
- Outlined diagnostic strategies for suspected excipient-induced anaphylaxis.
- Presented unresolved pathogenetic questions.
Conclusions:
- Increased awareness of anaphylaxis to drug excipients can improve recognition and diagnosis.
- Further research into pathogenesis may enhance diagnostic capabilities.
- Addressing the diagnostic gap is essential for managing allergic drug reactions.
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