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PD-L1 positive lympho-epithelial lesions in inflammatory prostate
Dorian Dikov1,2, Maria Koleva3, Kiril Simitchiev4
1Department of General and Clinical Pathology, Medical Faculty, Medical University of Plovdiv, Plodiv, Bulgaria.
Histology and Histopathology
|June 7, 2022
Summary
Lympho-epithelial lesions (LEL) are common in chronic prostatic inflammation (CI), especially high-grade inflammation. These PD-L1 positive lesions are part of the prostate
Area of Science:
- Uropathology
- Immunohistochemistry
- Prostate Cancer Research
Background:
- Ductal epithelial changes, specifically lympho-epithelial lesions (LEL), in the context of prostatic chronic inflammation (CI) have been understudied.
- Understanding these lesions is crucial for a comprehensive view of the inflammatory microenvironment within the prostate.
- LEL may play a role in the pathogenesis or progression of various prostatic conditions.
Purpose of the Study:
- To investigate the presence and characteristics of lympho-epithelial lesions (LEL) immediately adjacent to prostatic chronic inflammation (CI).
- To determine the association of LEL with different types and grades of prostatic inflammation.
- To assess the expression of PD-L1 in LEL within the prostate.
Main Methods:
- Analysis of 144 prostatic surgical and autopsy specimens.
- Inclusion of various types of prostatic CI: NIH-category IV prostatitis (histologic prostatitis-HP), nonspecific granulomatous prostatitis (NSGP), and reactive lymphoid infiltrates near benign prostatic hyperplasia (BPH) and prostate adenocarcinoma (PCa).
- Grading of CI as low (LG) and high grade (HG) based on inflammation severity; assessment of LEL and PD-L1 expression.
Main Results:
- LEL were identified in all studied prostatic specimens and CI types.
- Prevalence of LEL: 70.9% in HP, 100% in NSGP, 68.7% adjacent to BPH, and 80% adjacent to PCa.
- Significant correlation found between LEL presence and high-grade CI (p<0.001); LEL demonstrated strong membranous PD-L1 expression.
Conclusions:
- This study is the first to examine LEL in human inflammatory prostates.
- PD-L1 positive LEL are consistently found in high-grade chronic prostatic inflammation but lack organ specificity.
- LEL are integral components of prostate-associated lymphoid tissue (PALT) and the inflammatory prostatic microenvironment.
