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Methods of Ex Situ and In Situ Investigations of Structural Transformations: The Case of Crystallization of Metallic Glasses
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Detecting Crystallinity Using Terahertz Spectroscopy in 3D Printed Amorphous Solid Dispersions.

Supawan Santitewagun1, Rishi Thakkar2, J Axel Zeitler1

  • 1Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, U.K.

Molecular Pharmaceutics
|June 7, 2022
PubMed
Summary
This summary is machine-generated.

Terahertz time-domain spectroscopy (THz-TDS) effectively evaluates drug solid-state in 3D printed dosage forms. This advanced technique detects residual crystallinity missed by traditional methods, ensuring formulation stability.

Keywords:
3D printingAmorphous Solid DispersionsResidual CrystallinitySelective Laser SinteringTerahertz Time-Domain Spectroscopy

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Spectroscopy

Background:

  • Selective Laser Sintering (SLS) 3D printing offers novel manufacturing of amorphous solid dispersions (ASDs).
  • Ensuring the amorphous state of drugs in ASDs is crucial for formulation performance and stability.
  • SLS printing may yield partially amorphous systems, leading to reproducibility and storage issues.

Purpose of the Study:

  • To assess the utility of terahertz time-domain spectroscopy (THz-TDS) for characterizing the solid-state of drugs in SLS 3D printed dosage forms.
  • To compare THz-TDS with conventional techniques like differential scanning calorimetry (DSC) and powder X-ray diffractometry (pXRD).
  • To investigate THz-TDS's ability to detect residual crystallinity in granules used for 3D printing.

Main Methods:

  • Characterization of an SLS 3D printed amorphous solid dispersion using THz-TDS.
  • Comparative analysis with DSC and pXRD.
  • Evaluation of THz-TDS for detecting residual crystallinity in twin-screw granulated materials.

Main Results:

  • THz-TDS provided enhanced insights into the solid-state properties of the 3D printed dosage forms.
  • THz-TDS successfully identified residual crystallinity in granulated materials, a finding not detected by DSC or pXRD.
  • The study confirmed the applicability of THz-TDS in solid-state evaluation of 3D printed pharmaceuticals.

Conclusions:

  • THz-TDS is a valuable tool for detailed solid-state analysis of 3D printed amorphous solid dispersions.
  • This technique can identify subtle crystallinity issues missed by traditional methods, improving quality control.
  • THz-TDS aids in predicting the stability of amorphous solid dispersions manufactured via SLS 3D printing.