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Related Experiment Video

Updated: Sep 20, 2025

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
10:39

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Published on: August 30, 2024

812

Drug-Eluting Rubber Bands for Tissue Ligation.

Ron Feiner1, Eleanor Johns2,3, Merav Antman-Passig1

  • 1Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.

ACS Applied Materials & Interfaces
|June 7, 2022
PubMed
Summary

New drug-eluting rubber bands offer pain relief during tissue removal procedures. These bands release anesthetics for up to 5 days, improving patient comfort and adherence without compromising mechanical strength.

Keywords:
controlled releasedrug deliverydrug releaseelastomerhemorrhoidspain managementrubber

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Area of Science:

  • Biomaterials Engineering
  • Minimally Invasive Surgery
  • Pharmacology

Background:

  • Rubber band ligation is a common treatment for internal hemorrhoids, but causes significant post-procedure pain and discomfort.
  • Patient adherence and quality of life are negatively impacted by the pain associated with tissue sloughing after ligation.
  • Reducing side effects like pain is crucial for improving patient outcomes and treatment compliance.

Purpose of the Study:

  • To develop novel drug-eluting rubber bands for ligation procedures that reduce pain and discomfort.
  • To investigate the potential of these bands to elute anesthetics for durable pain management up to 5 days.
  • To ensure the drug-eluting bands retain mechanical properties similar to conventional rubber bands.

Main Methods:

  • Development of latex-free, drug-eluting rubber bands loaded with anesthetics.
  • Mechanical property testing to compare drug-eluting bands with conventional bands.
  • In vitro and in vivo studies to assess drug release, efficacy (cardiac cell calcium dynamics, zebrafish heart rate), and cytotoxicity.
  • Ex vivo studies to evaluate local drug release in enteric tissues.

Main Results:

  • Drug-loaded rubber bands maintained comparable mechanical properties to conventional bands.
  • Lidocaine released from the bands demonstrated in vitro efficacy by altering cardiomyocyte calcium dynamics and in vivo efficacy by modulating zebrafish embryo heart rate.
  • The developed bands exhibited lower cytotoxicity compared to conventional bands.
  • Ex vivo studies confirmed substantial local anesthetic release in enteric tissues.

Conclusions:

  • The novel latex-free, drug-eluting rubber bands possess suitable mechanical and drug-eluting properties for ligation procedures.
  • These bands can potentially serve dual functions of tissue ligation and local analgesia, reducing pain and improving patient quality of life.
  • This technology holds promise for pain reduction in various ligation-based treatments.