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Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
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All Glioblastoma Are Not Equal: Distinct Spatial Immune Profiles Between De Novo and Recurrent Tumors
Defne Bayik1,2, Juyeun Lee1, Justin D Lathia1,2
1Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Cancer Immunology Research
|June 7, 2022
Abstract:
Lack of insight into the immunosuppressive microenvironment of glioblastoma (GBM) hinders successful application of immunotherapy. In this issue, Alanio and colleagues identify a distinct T-cell localization profile between recurrent and de novo GBM highlighting the importance of spatial heterogeneity and providing new avenues to explore to improve GBM outcome. See related article by Alanio et al., p. 800 (3).
