Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hospital-initiated community pharmacist medication review post-discharge.

Aging clinical and experimental research·2026

Same author

A framework for building a synthetic cell from the SynCell Asia Initiative.

Nature biotechnology·2026

Same author

Preparation of Nanostructured FeCoNiMgO<sub><i>x</i></sub> Medium-Entropy Oxides by Using a Milk Template for Efficiently Promoting Oxygen Evolution Reaction.

Langmuir : the ACS journal of surfaces and colloids·2026

Same author

A Narrative Review on Unravelling Bacterial-Mediated Carcinogenesis and Possible Alternative Treatment Strategies.

BioMed research international·2026

Same author

The scientific legacy of Martin Karplus from the perspective of his collaborators.

Biophysical journal·2026

Same author

Matrix stiffness induces midnolin-dependent lamin B1 degradation to control myoblast differentiation.

EMBO reports·2026

Search research articles

Related Experiment Video

Updated: Sep 20, 2025

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

Long Non-Coding RNAs Profiling Using Microarray in Papillary Thyroid Carcinoma.

Farhadul Islam^1,2, Yaoqi Zhou³, Alfred K Lam^4,5,6

¹Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh. farhad_bio83@ru.ac.bd.

Methods in Molecular Biology (Clifton, N.J.)

|June 7, 2022

Summary

Long non-coding RNAs (lncRNAs) show altered expression in papillary thyroid carcinoma (PTC), acting as oncogenes or tumor suppressors. Profiling lncRNAs may offer new biomarkers for PTC patient management.

Keywords:

Cancer biomarkers LncRNA Microarray Non-coding RNAs Papillary thyroid carcinoma

More Related Videos

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

Profiling of Pre-micro RNAs and microRNAs using Quantitative Real-time PCR qPCR Arrays

Profiling of Pre-micro RNAs and microRNAs using Quantitative Real-time PCR qPCR Arrays

Published on: December 3, 2010

Related Experiment Videos

Last Updated: Sep 20, 2025

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

Profiling of Pre-micro RNAs and microRNAs using Quantitative Real-time PCR qPCR Arrays

Profiling of Pre-micro RNAs and microRNAs using Quantitative Real-time PCR qPCR Arrays

Published on: December 3, 2010

Area of Science:

Molecular Biology
Genomics
Oncology

Background:

Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in various cancers.
Their dysregulation is implicated in the pathogenesis of papillary thyroid carcinomas (PTCs).

Purpose of the Study:

To investigate the expression patterns of lncRNAs in PTC.
To explore the potential of lncRNAs as diagnostic and prognostic biomarkers in PTC.

Main Methods:

Genome-wide analysis (GWAS) was employed to identify differentially expressed lncRNAs in PTC tissues.
Microarray techniques were utilized to examine lncRNA expression profiles.

Main Results:

Specific lncRNAs were found to be upregulated (e.g., HOTAIR, NEAT1) or downregulated (e.g., MEG3, CASC2) in PTC tissues compared to non-cancerous samples.
The expression levels of certain lncRNAs correlated with clinicopathological parameters like metastasis and tumor stage.
Some lncRNAs, such as BANCR, exhibited dual roles as oncogenes or tumor suppressors depending on interactions.

Conclusions:

lncRNA expression profiles in PTC tissues can serve as potential prognostic or predictive biomarkers.
Microarray-based lncRNA analysis offers a valuable method for PTC research and potential clinical applications.