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Updated: Sep 20, 2025
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Synthesis and Performance Characterizations of Transition Metal Single Atom Catalyst for Electrochemical CO2 Reduction
Published on: April 10, 2018
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Homogeneous Organic Electron Donors in Nickel-Catalyzed Reductive Transformations
David J Charboneau1, Nilay Hazari1, Haotian Huang1
1Department of Chemistry, Yale University, P.O. Box 208107, New Haven, Connecticut 06520, United States.
The Journal of Organic Chemistry
|June 7, 2022
Summary
Homogeneous organic reductants offer advantages over traditional heterogeneous reductants in nickel-catalyzed cross-electrophile coupling (XEC) reactions. This perspective explores their potential for broader synthetic applications.
Area of Science:
- Organic Chemistry
- Catalysis
- Synthetic Methodology
Background:
- Many organic reactions, including Ni-catalyzed cross-electrophile coupling (XEC), rely on reductants.
- Heterogeneous reductants (e.g., Zn 0, Mn 0) are common but pose challenges for process scale and flow chemistry.
- Homogeneous organic reductants offer potential solutions and tunable reactivity.
Purpose of the Study:
- To review the progress of homogeneous organic electron donors in Ni-catalyzed XEC.
- To discuss the synthetic and mechanistic advantages of these reductants.
- To identify limitations and future challenges for their widespread adoption.
Main Methods:
- Literature review and perspective on homogeneous organic reductants in Ni-catalyzed XEC.
- Analysis of synthetic benefits and mechanistic insights.
- Discussion of limitations and future research directions.
Main Results:
- Homogeneous organic reductants can overcome limitations of heterogeneous reductants in XEC.
- They offer precise control over reductant strength and potential for new reactivity.
- Challenges remain in their broad implementation in synthetic chemistry.
Conclusions:
- Homogeneous organic reductants represent a promising alternative for reductive transformations.
- Further research is needed to address implementation challenges for wider synthetic utility.
- This approach has implications beyond XEC for various reductive processes.
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