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Updated: Sep 20, 2025

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
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Epidemiology of Valvular Heart Disease

Alex S Peters1, John P Duggan1, Gregory D Trachiotis2

  • 1Department of Surgery, Walter Reed National Military Medical Center, 4494 Palmer Road North, Bethesda, MD 20814, USA.

The Surgical Clinics of North America
|June 7, 2022
PubMed

Insights

Acquired valvular heart diseases, including aortic stenosis and mitral regurgitation, are significant causes of death. Aortic valve replacement offers a mortality benefit for aortic stenosis, while interventions for mitral regurgitation are increasing.

Area of Science:

  • Cardiology
  • Valvular Heart Disease
  • Public Health

Background:

  • Acquired valvular heart diseases are leading causes of morbidity and mortality.
  • Aortic stenosis (AS) incidence is rising in the US, linked to an aging population.
  • Mitral regurgitation (MR) is the most common valvular heart disease in the US, often due to mitral valve prolapse.

Purpose of the Study:

  • To summarize the current landscape of acquired aortic and mitral valve diseases.
  • To highlight the impact of demographic shifts on valvular heart disease prevalence.
  • To underscore the importance of interventions for these conditions.

Main Methods:

  • Literature review of valvular heart disease epidemiology.
  • Analysis of incidence trends for aortic stenosis and mitral regurgitation in the US.
  • Summary of current treatment outcomes for aortic stenosis and mitral regurgitation.

Main Results:

  • Aortic stenosis incidence is increasing in the US, driven by an aging population.
  • Aortic valve replacement demonstrates significant mortality benefits for AS.
  • Mitral regurgitation is prevalent in the US, with increasing interventional rates.

Conclusions:

  • Acquired valvular heart diseases represent a growing public health challenge.
  • Effective treatments like aortic valve replacement exist for AS.
  • Interventions for MR are becoming more common in the US.

Keywords:
Aortic valve stenosisCardiovascular diseasesHeart valve diseasesMitral valve Insufficiency

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