Related Experiment Video
Updated: Sep 20, 2025

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
The effect of legislation on firearm-related deaths in Canada: a systematic review
Nick Bennett1, Manolhas Karkada1, Mete Erdogan1
1Faculty of Medicine, Dalhousie University (Bennett, Karkada); Nova Scotia Health Trauma Program (Erdogan, Green), Nova Scotia Health; Departments of Emergency Medicine and Critical Care (Green), Dalhousie University, Halifax, NS.
Background:
Firearm misuse is common in cases of homicide, suicide and unintentional injury; this is a major public health issue, with societal and economic costs extending beyond the immediate injury or loss of life. We sought to review the evidence on the effectiveness of Canadian legislation in reducing deaths caused by firearms.
Methods:
Five databases (PubMed, Embase, CINAHL, Web of Science and Scopus) were searched from inception to May 2021 for studies evaluating the effect of Canadian gun control laws Bill C-51 (1977), Bill C-17 (1991) and Bill C-68 (1995) on rates of firearm-related death. Two reviewers performed article screening independently and in duplicate. We synthesized data using descriptive statistics. The primary outcome of interest was firearm-related mortality rates. Because of study heterogeneity, a meta-analysis was not performed.
Results:
Overall, 1479 articles were screened, and 18 studies were included. Ten studies examined the effect on homicides, of which 5 reported a reduction during the postlegislation period; 1 study reported evidence of substitution from firearms to other methods of homicide among people aged 15-24 years. Eleven studies evaluated the effect on suicides, with 9 finding a reduction in suicide rates. Eight of these studies reported evidence of substitution from firearms to other suicide methods. Two studies investigated accidental deaths; neither reported any benefit after legislation.
Interpretation:
Evidence supporting the effectiveness of Canadian firearms legislation in the reduction of homicide and accidental death rates is inconclusive; a decrease in firearm-related suicide rates was observed by most studies, but evidence of method substitution was also identified. Re-evaluation of existing laws may be beneficial to build an improved and effective evidence-based national framework for prevention of gun violence.
Prospero Registration:
CRD42020192486.
Related Concept Videos
Drug Regulation
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Drug Control Governance: Regulatory Bodies and Their Impact
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Bias in Epidemiological Studies
Criteria for Causality: Bradford Hill Criteria - II

