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Updated: Sep 20, 2025
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Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
Published on: May 16, 2019
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Cardiovascular Diseases and Zinc.
Serhan Ozyildirim1, Saltuk Bugra Baltaci2
1Department of Cardiology, Cardiology Institute, Istanbul University-Cerrahpasa, Istanbul, Turkey. serhan.ozyildirim@iuc.edu.tr.
Biological Trace Element Research
|June 7, 2022
Summary
Zinc is vital for heart development and function, impacting enzymes and transcription factors. This review explores zinc
Area of Science:
- Biochemistry
- Cardiovascular Biology
- Human Physiology
Background:
- Zinc is essential for over 300 enzymes and 2000 transcription factors.
- Intracellular labile zinc concentration critically influences cellular signaling and enzymatic activity.
- Zinc plays a key role in embryonic heart development and is linked to congenital heart defects.
Purpose of the Study:
- To review the complex relationship between zinc and the cardiovascular system.
- To highlight zinc's roles in both healthy and diseased cardiovascular states.
- To elucidate zinc's involvement in cardiovascular development and pathology.
Main Methods:
- Literature review of existing studies on zinc and cardiovascular health.
- Analysis of zinc's biochemical functions in relation to cardiovascular processes.
- Examination of clinical and experimental data on zinc levels in cardiovascular diseases.
Main Results:
- Zinc is crucial for heart morphogenesis, including septation and valve development.
- Zinc is implicated in monocyte-macrophage pathways relevant to atherosclerosis.
- Intracellular zinc modulates calcium signaling, affecting heart failure and hypertension, while extracellular zinc has opposing effects.
Conclusions:
- Zinc has multifaceted roles in cardiovascular health and disease.
- The complex zinc-cardiovascular system interplay requires further comprehensive explanation.
- Understanding zinc's dual intra- and extracellular effects is key to cardiovascular research.
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