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Biological aspects in controlling angiogenesis: current progress.

Mohsen Akbarian¹, Luiz E Bertassoni², Lobat Tayebi³

¹Department of Chemistry, National Cheng Kung University, Tainan, 701, Taiwan.

Cellular and Molecular Life Sciences : CMLS

|June 7, 2022

Summary

This summary is machine-generated.

Angiogenesis, the formation of new blood vessels, is crucial for life but can be dysregulated in diseases like cancer and diabetes. This review explores factors controlling angiogenesis and strategies for its therapeutic manipulation in tissue engineering.

Keywords:

Angiogenesis Anti-angiogenics Pro-angiogenics Tissue engineering Vascularization

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Area of Science:

Biomedical Engineering
Cell Biology
Physiology

Background:

Angiogenesis is vital for nutrient and waste transfer to cells via arteries.
This process naturally occurs during puberty, wound healing, and exercise adaptation.
Dysregulated angiogenesis is implicated in diseases like cancer and diabetes.

Purpose of the Study:

To review the factors controlling angiogenesis.
To discuss current strategies for stimulating or inhibiting angiogenesis.
To explore angiogenesis strategies in tissue engineering, considering mechanical factors.

Main Methods:

Literature review of angiogenesis mechanisms.
Analysis of factors influencing angiogenesis.
Discussion of therapeutic and tissue engineering applications.

Main Results:

Angiogenesis is a tightly regulated process with dual roles in health and disease.
Both excessive and insufficient angiogenesis present significant clinical challenges.
Therapeutic strategies aim to modulate angiogenesis for disease treatment and tissue repair.

Conclusions:

Understanding angiogenesis control is key for treating diseases like cancer and diabetes.
Targeting angiogenesis offers therapeutic potential in regenerative medicine and tissue engineering.
Mechanical forces significantly influence angiogenesis, impacting tissue engineering strategies.