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Toll like receptor 4 gene Asp299Gly polymorphism increases the risk of diabetic microvascular complications: a meta

Yuqi Zhang1,2, Huanhuan Li1,2, Chenyi Wang1,2

  • 1Department of Endocrinology, The First Hospital of Lanzhou University, No. 1 Donggang West Road, Lanzhou, 730000, Gansu, People's Republic of China.

Diabetology & Metabolic Syndrome
|June 7, 2022
PubMed
Abstract

Insights

The Toll like receptor 4 (TLR4) Asp299Gly gene variant increases the risk of microvascular complications in type 2 diabetes. This risk is particularly elevated for diabetic retinopathy in Caucasian populations.

Area of Science:

  • Genetics
  • Immunology
  • Endocrinology

Background:

  • Diabetic microvascular complications (DMI) are a major cause of morbidity in type 2 diabetes mellitus (T2DM).
  • The role of genetic factors, such as Toll like receptor 4 (TLR4) gene polymorphisms, in DMI development requires further elucidation.

Purpose of the Study:

  • To conduct a meta-analysis investigating the association between the TLR4 gene Asp299Gly polymorphism and DMI in patients with T2DM.
  • To explore potential subgroup differences based on ethnicity and specific microvascular complications.

Main Methods:

  • A systematic literature search was performed across multiple databases (PubMed, Web of Science, Springer, Cochrane Library, ELSEVIER, Wanfang, VIP, CNKI) for case-control studies.
  • Studies published before June 2020 correlating TLR4 Asp299Gly polymorphism with DMI were included.

Main Results:

  • The meta-analysis included 6 articles comprising 11 studies (1834 cases with DMI, 4069 controls).
  • TLR4 Asp299Gly polymorphism was significantly associated with an increased risk of DMI in T2DM patients (dominant model OR=1.52, P=0.01; allelic model OR=1.42, P=0.04).
  • Subgroup analyses revealed a stronger association in Caucasians and an increased risk of diabetic retinopathy (DR).

Conclusions:

  • The TLR4 gene Asp299Gly polymorphism is linked to a higher risk of microvascular complications in T2DM patients.
  • This genetic variant is particularly associated with an increased risk of diabetic retinopathy.
Keywords:
Asp299Gly(rs4986790, 896A > G)Diabetic microvascular complications (DMI)Gene polymorphismMeta analysisToll like receptor 4 (TLR4)

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