Related Experiment Video
Updated: Sep 20, 2025

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
Transcatheter Occlusion of a Patent Ductus Arteriosus for a Symptomatic Left-to-Right Shunt
Papus Keita1, Frank Han2, Nicholas J Peterman3
1Surgery, Carle Foundation Hospital, Urbana, USA.
Insights
Congenital diaphragmatic hernias can cause severe heart and lung issues. This study reports a rare case of transcatheter closure for a hemodynamically significant patent ductus arteriosus in CDH patients.
Area of Science:
- Pediatric Cardiology
- Interventional Cardiology
- Neonatal Physiology
Background:
- Congenital diaphragmatic hernia (CDH) frequently leads to pulmonary hypertension and right heart failure.
- A patent ductus arteriosus (PDA) is often necessary in CDH for circulatory decompression.
- Hemodynamically significant PDAs may require intervention.
Observation:
- This report details a rare instance of transcatheter closure.
- The intervention addressed a hemodynamically significant PDA in a patient with CDH.
- This approach was used when traditional methods were insufficient or not preferred.
Findings:
- Successful transcatheter closure of a hemodynamically significant PDA was achieved.
- The procedure offered an alternative to pharmacological closure methods.
- This case highlights the feasibility of interventional closure in complex neonatal cases.
Implications:
- Transcatheter closure represents a viable therapeutic option for hemodynamically significant PDAs in CDH.
- This technique may improve outcomes for neonates with CDH-related cardiovascular complications.
- Further research could explore the long-term efficacy and safety of this interventional approach.
Abstract:
Congenital diaphragmatic hernias (CDH) can induce life-threatening pulmonary hypertension and right heart failure. The patent ductus arteriosus (PDA) is often maintained in CDH to allow for decompression into the systemic circulation. However, if the PDA becomes hemodynamically significant, PDA closure may be indicated. Traditional methods rely on pharmacological closure. In this report, we document a rare transcatheter closure of a hemodynamically significant PDA.
Related Concept Videos
Cardiac Catheterization III: Left Heart Catheterization
Cardiac Catheterization II: Right Heart Catheterization

