Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhanced Intramuscular mRNA Activity of Peptide-Lipid Nanoparticles with Hydrophobized Head Groups.

Bioconjugate chemistry·2026
Same author

Adipose Tissue-Targeted Delivery of Rosiglitazone With Iron Oxide Nanoparticles Ameliorates Insulin Resistance in Male Mice.

Obesity (Silver Spring, Md.)·2026
Same author

Hydrophobic Refinement of Polarity-Switchable Lipo-Xenopeptides Modulates Endosomal Escape and Enhances mRNA Delivery In Vitro and In Vivo.

Journal of the American Chemical Society·2026
Same author

CRISPR/Cas9 Ribonucleoprotein Delivery Enhanced by Lipo-Xenopeptide Carriers and Homology-Directed Repair Modulators: Insights from Reporter Cell Lines.

International journal of molecular sciences·2025
Same author

Nanogel encapsulation improves pharmacokinetics and biodistribution of antimicrobial peptide LL37 upon lung deposition: In vivo evaluation by SPECT/CT.

Journal of controlled release : official journal of the Controlled Release Society·2025
Same author

Liposomal lipid nanoparticles for extrahepatic delivery of mRNA.

Nature communications·2025

Related Experiment Video

Updated: Sep 20, 2025

Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment
10:33

Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment

Published on: April 25, 2025

399

Aptamers used for molecular imaging and theranostics - recent developments.

Lennart Bohrmann1,2, Tobias Burghardt1, Charles Haynes3

  • 1Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.

Theranostics
|June 8, 2022
PubMed
Summary

Aptamers, or single-stranded DNA/RNA, are versatile tools for molecular imaging and therapy. This review highlights their in vivo applications in various imaging techniques and diagnostics.

Keywords:
in vivo imagingAptamersdrug deliverymolecular imagingnanomedicine

More Related Videos

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

6.8K
Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
10:47

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

8.9K

Related Experiment Videos

Last Updated: Sep 20, 2025

Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment
10:33

Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment

Published on: April 25, 2025

399
Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

6.8K
Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
10:47

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

8.9K

Area of Science:

  • Biotechnology and Biomedical Engineering
  • Molecular Imaging and Diagnostics
  • Theranostics

Background:

  • Aptamers are single-stranded oligonucleotides with high specificity and affinity for molecular targets, similar to antibodies.
  • Their chemical versatility makes them suitable for developing targeted probes for in vivo applications.
  • Aptamers are increasingly used in diverse imaging modalities and for in vivo sensing.

Purpose of the Study:

  • To review in vivo studies of aptamer-based probes for molecular imaging.
  • To examine the application of aptamers in theranostics (combined diagnosis and therapy).
  • To provide an updated overview since the 2018 review by Bouvier-Müller and Ducongé.

Main Methods:

  • Literature review of in vivo studies involving aptamer-based probes.
  • Analysis of aptamer applications across various imaging modalities (nuclear, MRI, CT, ultrasound, fluorescence, SERS).
  • Examination of aptamer-based sensors for in vivo cellular marker detection.

Main Results:

  • Aptamer probes have been successfully applied in numerous in vivo imaging modalities.
  • Aptamers demonstrate potential for targeted therapy and theranostic applications.
  • In vivo aptamer-based sensors enable localized detection of biomarkers like ATP.

Conclusions:

  • Aptamer-based probes are highly effective for in vivo molecular imaging and theranostics.
  • Their versatility and specificity offer significant advantages over traditional probes.
  • Continued research in aptamer technology promises advancements in medical diagnostics and treatment.