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Evaluation of injuries caused by coronavirus disease 2019 using multi-nuclei magnetic resonance imaging
Qian Zhou1,2, Qiuchen Rao1, Haidong Li1,2
1Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Wuhan, 430071, China.
Insights
This review explores how advanced magnetic resonance imaging (MRI) techniques, including multi-nuclei and hyperpolarized 129Xe gas MRI, can assess organ damage from COVID-19. These methods offer insights into lung, brain, and heart injuries caused by the virus.
Area of Science:
- Medical Imaging
- Radiology
- Pulmonology
Background:
- Coronavirus disease 2019 (COVID-19) poses a significant global health challenge.
- Chest radiography and CT are crucial for COVID-19 diagnosis and complication detection.
- Magnetic resonance imaging (MRI) offers superior soft tissue contrast and functional assessment capabilities.
Purpose of the Study:
- To review recent advancements in multi-nuclei MRI for evaluating COVID-19 related organ injuries.
- To discuss clinical 1H MRI applications for assessing lung, brain, and heart damage in COVID-19 patients.
- To explore the emerging role of hyperpolarized 129Xe gas MRI in evaluating pulmonary abnormalities.
Main Methods:
- Review of recent scientific literature on MRI techniques for COVID-19.
- Focus on multi-nuclei MRI, clinical 1H MRI, and hyperpolarized 129Xe gas MRI.
- Analysis of applications in diagnosing and assessing organ damage.
Main Results:
- Multi-nuclei MRI is valuable for diagnosing COVID-19 and evaluating organ injuries.
- Clinical 1H MRI techniques are applied to assess lung, brain, and heart damage.
- Hyperpolarized 129Xe gas MRI shows promise for evaluating pulmonary structural and functional changes.
Conclusions:
- Advanced MRI techniques, including multi-nuclei and hyperpolarized 129Xe gas MRI, are essential tools for understanding and managing COVID-19.
- These imaging modalities provide critical insights into the multi-organ impact of the disease.
- Further research and clinical application of these MRI techniques are warranted for comprehensive COVID-19 patient care.
Abstract:
The ongoing pandemic of coronavirus disease 2019 (COVID-19) has been a great burden for the healthcare system in many countries because of its high transmissibility, severity, and fatality. Chest radiography and computed tomography (CT) play a vital role in the diagnosis, detection of complications, and prognostication of COVID-19. Additionally, magnetic resonance imaging (MRI), especially multi-nuclei MRI, is another important imaging technique for disease diagnosis because of its good soft tissue contrast and the ability to conduct structural and functional imaging, which has also been used to evaluate COVID-19-related organ injuries in previous studies. Herein, we briefly reviewed the recent research on multi-nuclei MRI for evaluating injuries caused by COVID-19 and the clinical 1H MRI techniques and their applications for assessing injuries in lungs, brain, and heart. Moreover, the emerging hyperpolarized 129Xe gas MRI and its applications in the evaluation of pulmonary structures and functional abnormalities caused by COVID-19 were also reviewed.
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