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Updated: Sep 20, 2025
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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Triggers of migraine: where do we stand?
D Martinelli1,2, M M Pocora1,2, R De Icco1,2
1Department of Brain and Behavioral Sciences, University of Pavia, Pavia.
Current Opinion in Neurology
|June 8, 2022
Summary
Migraine attacks may require multiple triggers acting together, not just one. Differentiating true migraine triggers from early symptoms is crucial for effective patient management.
Area of Science:
- Neurology
- Epidemiology
- Pathophysiology
Background:
- Migraine triggers are commonly reported by patients, affecting up to 75.9%.
- Distinguishing triggers from premonitory symptoms is essential for accurate diagnosis and treatment.
- Understanding trigger mechanisms is key to managing migraine effectively.
Purpose of the Study:
- To review current findings on migraine trigger epidemiology and pathophysiology.
- To discuss the clinical implications of migraine triggers.
- To differentiate true triggers from premonitory symptoms.
Main Methods:
- Literature review of recent findings on migraine triggers.
- Analysis of epidemiological data and pathophysiological mechanisms.
- Discussion of clinical practice implications.
Main Results:
- Individual triggers may not provoke migraine attacks in isolation.
- Combined triggers might be necessary to induce migraine by causing brain dysfunction.
- Some patient-reported triggers may be early migraine manifestations, not causative factors.
Conclusions:
- Accurate identification of migraine triggers is vital for effective management strategies.
- Avoiding non-validated triggers can prevent patient frustration and ineffective treatment.
- Further research into the synergistic effects of triggers is warranted.
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