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Related Concept Videos

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Replicative Cell Senescence

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Related Experiment Video

Updated: Sep 20, 2025

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
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Cellular senescence and the tumour microenvironment.

Masaki Takasugi1, Yuya Yoshida1, Naoko Ohtani1

  • 1Department of Pathophysiology, Graduate School of Medicine, Osaka Metropolitan University (formerly, Osaka City University), Osaka, Japan.

Molecular Oncology
|June 8, 2022
PubMed
Summary

Senescent cells release factors (SASP) impacting the tumor microenvironment. Their dual role in cancer suppression or promotion depends on context, influencing therapy strategies like senolytics and senomorphics.

Keywords:
anti-tumour immunitycellular senescencesenescence-associated secretory phenotypesenolysissenomorphicstumour microenvironment

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Area of Science:

  • Oncology
  • Cellular Biology
  • Immunology

Background:

  • Cellular senescence triggers the senescence-associated secretory phenotype (SASP).
  • SASP involves secreting cytokines, chemokines, and growth factors.
  • SASP's role in the tumor microenvironment is context-dependent.

Purpose of the Study:

  • To review the features and roles of senescent cells in the tumor microenvironment.
  • To emphasize the context-dependency of SASP in cancer development.
  • To discuss senolytics and senomorphics for cancer therapy.

Main Methods:

  • Literature review of cellular senescence and SASP.
  • Analysis of SASP's dual role (tumor-suppressive and tumor-promoting).
  • Discussion of therapeutic strategies targeting senescent cells.

Main Results:

  • SASP influences stromal, immune, and cancer cells via paracrine effects.
  • Senescence can suppress tumors (surveillance) or promote them (immune suppression).
  • The impact of SASP is determined by cell type and senescence induction.

Conclusions:

  • Senescent cells and SASP have complex, context-specific roles in cancer.
  • Targeting senescent cells with senolytics or senomorphics shows therapeutic potential.
  • Understanding SASP's dual role is crucial for effective cancer treatment.