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Application of Induced Pluripotent Stem Cells in Moyamoya Disease: Progress and Promises

Yimeng Xue1,2, Qian Zhang2,3,4,5, Lin-Jian Wang1,2

  • 1Savaid Medical School, University of Chinese Academy of Sciences, Beijing China.

Current Stem Cell Research & Therapy
|June 8, 2022
PubMed

Insights

Moyamoya disease (MMD) research is advanced by induced pluripotent stem cells (iPSC), offering a solution to limited tissue samples. iPSC technology promises to uncover MMD

Area of Science:

  • Neurology
  • Genetics
  • Stem Cell Biology

Background:

  • Moyamoya disease (MMD) is a chronic cerebrovascular disorder characterized by steno-occlusion and abnormal vascular networks.
  • The precise etiology of MMD remains unclear, largely due to a scarcity of pathological specimens.
  • This limitation hinders comprehensive research into the disease's underlying mechanisms.

Approach:

  • This review explores the application of induced pluripotent stem cells (iPSC) in MMD research.
  • iPSCs, derived from patients, possess significant differentiation potential and self-renewal capacity.
  • Utilizing iPSCs overcomes the challenge of insufficient sample availability for mechanistic studies.

Key Points:

  • iPSC technology offers a powerful tool to investigate the molecular mechanisms driving MMD development.
  • Recent advancements and persistent challenges in MMD mechanism research are discussed.
  • The review highlights the potential of iPSCs in elucidating MMD pathogenesis.

Conclusions:

  • Induced pluripotent stem cells represent a promising avenue for understanding MMD.
  • Further research utilizing iPSCs could pave the way for novel therapeutic strategies for MMD.
  • This approach holds potential for personalized medicine in treating Moyamoya disease.
Keywords:
Induced pluripotent stem cellcerebral vascular diseaseendothelial cellmoyamoya diseasering finger protein 213vascular smooth muscle cell

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