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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
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Metabolic evaluation: is there really a future?

Olivier Traxer1,2, Mariela Corrales1,2, Alba Sierra1,2

  • 1Sorbonne University GRC Urolithiasis no. 20 Tenon Hospital.

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A metabolic evaluation is crucial for kidney stone formers due to rising urolithiasis and associated metabolic abnormalities. Early and comprehensive analysis, including blood and urine tests, aids in diagnosis and personalized treatment.

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Area of Science:

  • Nephrology
  • Urology
  • Metabolic Medicine

Background:

  • Urolithiasis (kidney stone disease) prevalence has increased globally since 1990.
  • Associated metabolic abnormalities like hyperuricosuria, hyperoxaluria, and hypocitraturia are also rising.
  • These abnormalities are key contributors to kidney stone formation.

Purpose of the Study:

  • To determine the necessity of metabolic evaluation for kidney stone formers.
  • To align with the latest research (last 24 months) and 2022 urological guidelines.
  • To emphasize early detection of metabolic derangements.

Main Methods:

  • Review of recent scientific literature on urolithiasis and metabolic abnormalities.
  • Analysis of current 2022 American and European urological guidelines.
  • Emphasis on comprehensive metabolic analysis including blood tests and 24-hour urine analysis, supplemented by fresh urine analysis.

Main Results:

  • Metabolic abnormalities are increasingly prevalent in stone formers.
  • These abnormalities are detectable only through specific metabolic evaluations.
  • Stone type identification correlates with the need for further metabolic parameter assessment.

Conclusions:

  • Metabolic evaluation is essential for all patients with urolithiasis.
  • Initial basic metabolic analysis should be standard, followed by in-depth analysis based on risk stratification.
  • Integrating stone analysis with metabolic evaluation guides effective management.