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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Sep 20, 2025

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
06:10

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

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Microencapsulation-based cell therapies.

Safiya Naina Marikar1, Assam El-Osta1, Angus Johnston2

  • 1Epigenetics in Human Health and Disease, Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.

Cellular and Molecular Life Sciences : CMLS
|June 8, 2022
PubMed
Summary
This summary is machine-generated.

Microencapsulation protects epigenetically regenerated cells, offering a promising therapeutic strategy for diseases like Type 1 Diabetes. Further material development is needed to enhance transplanted cell survival and therapeutic efficacy.

Keywords:
B-cell transplantationCardiacCell reprogrammingLiverMicroencapsulation technologiesNeural tissue repairTissue repairType 1 diabetes

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Area of Science:

  • Regenerative Medicine
  • Nanomedicine
  • Immunology

Background:

  • Epigenetic agents offer a novel approach for regenerating cells to treat diseases such as Type 1 Diabetes and cardiomyopathy.
  • Transplanted epigenetically regenerated cells face immunological barriers and limitations in longevity and potency.

Purpose of the Study:

  • To explore microencapsulation as a strategy to protect epigenetically regenerated cells from immune rejection.
  • To highlight the potential of microencapsulation in various therapeutic applications, including islet transplantation and tissue repair.

Main Methods:

  • Review of current microencapsulation strategies for cell therapy.
  • Discussion of recent advancements in nanomedicine relevant to cell protection and longevity.

Main Results:

  • Microencapsulation provides a protective barrier against host immune responses for transplanted cells.
  • Promising clinical findings support microencapsulation for islet transplantation, cardiac, hepatic, and neuronal repair.

Conclusions:

  • Microencapsulation is a key strategy for overcoming immunological barriers in cell transplantation.
  • Development of advanced materials is crucial for improving the long-term survival and efficacy of encapsulated cells in regenerative medicine.