Anticancer effects of marine compounds blocking the nuclear factor kappa B signaling pathway

Area of Science:

• Marine Biotechnology
• Cancer Biology
• Pharmacology

Background:

• Abnormal expression of nuclear factor kappa B (NF-κB) target genes is linked to tumor occurrence, metastasis, invasion, and apoptosis inhibition.
• Marine biodiversity offers a rich source of novel compounds with potential therapeutic applications.

Purpose of the Study:

• To review marine compounds that exhibit anticancer effects by modulating the NF-κB signaling pathway.
• To consolidate information on marine-derived compounds for researchers in drug development.

Main Methods:

• Literature review of studies on marine compounds and their effects on cancer cell survival.
• Analysis of compounds derived from sponges, fungi, and algae.
• Examination of modulation of canonical, noncanonical, and atypical NF-κB signaling pathways.

Main Results:

• Identified 26 marine compounds that reduce cancer cell survival by suppressing the NF-κB pathway.
• These compounds originate from diverse marine organisms like sponges, fungi, and algae.
• Antitumor effects are mediated through various NF-κB signaling routes.

Conclusions:

• Marine compounds represent a promising avenue for developing novel anticancer drugs.
• Further research is required to elucidate the precise anticancer targets and mechanisms of these compounds.
• This review provides a valuable resource for marine compound bioactivity research.