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Updated: Sep 20, 2025
In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
A novel immune-related microRNA signature for prognosis of thymoma
Bin Wang1,2, He Xiao2, Xin Yang3
1Department of Cell Biology and Genetics, Chongqing Medical University, Chongqing 400016, China.
Introduction:
Immune microenvironment and microRNAs serve as common predictors for diagnosis and prognosis of tumors.
Methods:
Expression of 122 genes and 126 microRNAs in thymoma was obtained from TCGA database. The proportion of tumor-infiltrating cells was calculated, and IMRS was constructed. TREM2hi score was calculated before functional enrichment analysis on gene sets.
Results:
IMRS3, TREM2hi score, and CD8+ T lymphocyte abundance were significantly different among WHO classifications. WHO classification, Masaoka staging, and miR-130b-5p, miR-1307-3p, miR-425-5p, CD8, CD68, and CCL18 expression were prognostic factors for relapse-free survival and overall survival. IMRS3 upregulation polarized macrophages into M2, which rejected CD8+ T and other effector lymphocytes to promote thymoma malignant progression.
Conclusions:
BRRS may present a novel immune-related microRNA signature for TET prognosis.
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