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Patient-Relevant Outcomes in Psoriasis: A Systematic Review
Niels Hilhorst1,2, Elfie Deprez1,2, Nele Pauwels3
1Dermatology Research Unit, Ghent University, Ghent, Belgium.
JAMA Dermatology
|June 8, 2022
Summary
Patients with psoriasis identified 23 key outcomes, including symptom control, daily activities, and emotional well-being, crucial for value-based care. This research highlights patient-centered priorities in psoriasis management.
Area of Science:
- Dermatology and Patient-Reported Outcomes
Background:
- Psoriasis management requires understanding patient-valued outcomes for effective, value-based care.
- A gap exists in comprehensively defining outcomes most important to individuals with psoriasis.
Purpose of the Study:
- To systematically review and synthesize patient-defined outcomes relevant to psoriasis management.
- To establish a comprehensive overview of what matters most to patients with psoriasis.
Main Methods:
- Systematic literature review of MEDLINE, Embase, and Web of Science (August 2019 - March 2021).
- Inclusion criteria focused on studies reporting outcome importance for psoriasis patients.
- Data extraction and quality assessment using QUALSYST tool by two independent reviewers.
Main Results:
- 24 studies involving 23,317 patients were synthesized, identifying 273 items aggregated into 23 distinct outcomes.
- Key outcomes include symptom control, treatment efficacy, daily/social activities, emotional well-being, and quality of life.
- Outcomes were categorized into physical/clinical, life impact, resource use, and adverse effects.
Conclusions:
- This review provides a patient-centered framework for psoriasis outcomes, essential for transitioning to value-based healthcare.
- Understanding these patient-relevant outcomes can guide clinical practice and research priorities in psoriasis.
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