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Primary lymphoma of the breast
The British Journal of Surgery
|March 1, 1987
Summary
Primary breast lymphoma is rare but awareness may be increasing. Prognosis depends on tumor type and stage, with survival rates comparable to or better than other lymphomas or breast cancer.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Primary breast lymphoma is a rare malignancy.
- A 30-year review identified 15 cases, with 8 diagnosed in the last 5 years, suggesting increased incidence or awareness.
- Patients presented with breast mass, often with axillary node involvement.
Purpose of the Study:
- To review the incidence, clinical presentation, treatment, and outcomes of primary breast lymphoma.
- To analyze factors influencing prognosis and survival.
Main Methods:
- Retrospective review of 15 patients diagnosed with primary breast lymphoma over 30 years.
- Analysis of patient demographics, tumor characteristics, treatment modalities (surgery, radiotherapy, chemotherapy), and follow-up data.
Main Results:
- The age range was 17-77 years. One case was Hodgkin's disease; the rest were non-Hodgkin's lymphoma.
- Three patients developed contralateral breast involvement; three died from the disease.
- Prognosis was linked to high-grade centroblastic lymphoma, large tumor size, and nodal involvement.
- Five-year survival was 85%; ten-year survival was 73%.
Conclusions:
- Primary breast lymphoma outcomes are influenced by histology and disease stage.
- Survival rates for primary breast lymphoma appear favorable compared to other extranodal lymphomas and breast cancer.