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Related Concept Videos

External Anatomy of the Kidney01:21

External Anatomy of the Kidney

1.7K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
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Kidney Structure01:45

Kidney Structure

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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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Internal Anatomy of the Kidney01:12

Internal Anatomy of the Kidney

2.9K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
2.9K
Anatomy of the Genitourinary System I: Kidneys and Ureters01:11

Anatomy of the Genitourinary System I: Kidneys and Ureters

107
The upper urinary system comprises two kidneys and two ureters, which are crucial in filtering blood and forming urine.KidneysLocation and Structure:The kidneys are two bean-shaped organs positioned behind the peritoneum on either side of the spine.Kidneys are between the 12th thoracic (T12) and the 3rd lumbar (L3) vertebrae.The position of the liver causes the right kidney to sit slightly lower than the left.Protective Layers:Each kidney is enveloped in a tough, fibrous membrane called the...
107
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

48
Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
48
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

65
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Related Experiment Video

Updated: Sep 20, 2025

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue
05:46

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue

Published on: June 9, 2020

4.0K

A reference tissue atlas for the human kidney.

Jens Hansen1, Rachel Sealfon2,3, Rajasree Menon4

  • 1Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Science Advances
|June 8, 2022
PubMed
Summary
This summary is machine-generated.

The Kidney Precision Medicine Project (KPMP) created a detailed human kidney atlas. This single-cell resolution map links kidney cells, genes, and pathways, aiding in disease classification.

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Generation of Human Kidney Tubuloids from Tissue and Urine
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3D Imaging of Soft-Tissue Samples using an X-ray Specific Staining Method and Nanoscopic Computed Tomography
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Last Updated: Sep 20, 2025

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue
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Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue

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Generation of Human Kidney Tubuloids from Tissue and Urine
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3D Imaging of Soft-Tissue Samples using an X-ray Specific Staining Method and Nanoscopic Computed Tomography
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Area of Science:

  • Nephrology
  • Genomics
  • Proteomics
  • Metabolomics
  • Systems Biology

Background:

  • The Kidney Precision Medicine Project (KPMP) aims to build a spatially defined human kidney atlas.
  • Understanding kidney cell function in health and disease requires high-resolution molecular data.

Purpose of the Study:

  • To construct an integrated reference map of kidney cells, pathways, and genes at single-cell resolution.
  • To establish a framework for classifying kidney diseases based on molecular mechanisms.

Main Methods:

  • Utilized unaffected nephrectomy tissues and biopsies from 56 adult subjects.
  • Employed single-cell/nucleus transcriptomics, laser microdissection transcriptomics and proteomics, near-single-cell proteomics, 3D and CODEX imaging, and spatial metabolomics.
  • Integrated multi-omic data to hierarchically identify genes, pathways, and cell types.

Main Results:

  • Successfully identified and mapped cell types and subtypes within nephron segments and the interstitium.
  • Characterized cell-level functional organization of the kidney, linking cell subtypes to genes, proteins, metabolites, and pathways.
  • Demonstrated congruence between messenger RNA levels along the nephron and subsegmental physiological activity.

Conclusions:

  • The developed reference atlas provides a comprehensive resource for kidney research.
  • This atlas enables a new framework for classifying kidney diseases by integrating molecular data.
  • The findings highlight the utility of multi-omic, spatially resolved data for understanding kidney physiology and pathology.