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Oxidative Stress and Menopausal Status: The Coronary Artery Risk Development in Young Adults Cohort Study.
Amir S Heravi1, Erin D Michos2, Di Zhao3
1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Journal of Women'S Health (2002)
|June 8, 2022
Summary
Postmenopausal women exhibit higher oxidative stress, indicated by elevated urinary isoprostane levels, compared to premenopausal women. This finding suggests a potential link between menopause and increased cardiovascular disease risk.
Area of Science:
- Cardiovascular Health
- Endocrinology
- Biomarkers of Oxidative Stress
Background:
- Low estrogen levels post-menopause are linked to increased oxidative stress and cardiovascular disease (CVD) risk.
- Population-level data comparing oxidative stress in premenopausal and postmenopausal women is limited.
Purpose of the Study:
- To investigate differences in systemic oxidative stress between premenopausal and postmenopausal women.
- To determine if menopause is associated with higher urinary isoprostane concentrations, a marker of oxidative stress.
Main Methods:
- Analysis of urinary 8-isoprostane (iPF2α-III) and 2,3-dinor-8-isoprostane (iPF2α-III-M) indexed to creatinine.
- Comparison between 279 postmenopausal and 196 premenopausal women from the Coronary Artery Risk Development in Young Adults (CARDIA) study.
- Linear regression models adjusted for sociodemographic and traditional CVD risk factors.
Main Results:
- Postmenopausal women showed significantly higher unadjusted urinary iPF2α-III-M concentrations.
- Menopause was associated with a 25.5% increase in iPF2α-III-M, with partial attenuation after adjusting for confounders.
- The association between menopause and higher iPF2α-III was observed in Black women but not White women.
Conclusions:
- Postmenopausal status is linked to elevated systemic oxidative stress.
- Increased oxidative stress in postmenopausal women may contribute to their heightened cardiovascular disease risk.
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