Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Sep 20, 2025

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids
10:23

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids

Published on: May 3, 2024

1.0K

Biomaterial functionalization with triple-helical peptides for tissue engineering.

Jean-Daniel Malcor1, Frédéric Mallein-Gerin1

  • 1Laboratory of Tissue Biology and Therapeutic Engineering, CNRS UMR 5305, University Claude Bernard-Lyon 1 and University of Lyon, 7 Passage du Vercors, Cedex 07, Lyon 69367, France.

Acta Biomaterialia
|June 8, 2022
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Stiffness and Cell-Binding Motif Availability on the Cell-Specific Response to Collagen-Based Macromolecular Materials.

Biomacromolecules·2026
Same author

Structural basis for collagen recognition by the <i>Streptococcus pyogenes</i> M3 protein and its involvement in biofilm.

eLife·2025
Same author

Corrigendum to "Presence of type IIB procollagen in mouse articular cartilage and growth plate is revealed by immuno-histochemical analysis with a novel specific antibody" [Matrix Biol. Plus 18 (2023) 100130].

Matrix biology plus·2025
Same author

In silico and in vitro characterization of GH12, an innovative peptide for dental pulp regeneration.

Journal of dentistry·2025
Same author

Antimicrobial GH12-fibrin hydrogel for dental pulp regeneration: An in vitro study.

Dental materials : official publication of the Academy of Dental Materials·2025
Same author

Deciphering the folding code of collagens.

Nature communications·2025
Same journal

Thermoresponsive hydrogel for long-acting delivery of structurally intact and biologically active Fab fragment and monoclonal antibody.

Acta biomaterialia·2026
Same journal

Cell crowding initiates tumor invasion by triggering a nanoscale topography transition of plasma membranes.

Acta biomaterialia·2026
Same journal

Mechanical properties, polymerization, and humidity effects on the egg glue of the Southern green stink bug, Nezara viridula L. (Hemiptera: Pentatomidae).

Acta biomaterialia·2026
Same journal

Hierarchical dual-conductive networks enable high-cell-density spheroid bioprinting for volumetric muscle loss repair.

Acta biomaterialia·2026
Same journal

A flap mechanics testbed for skin reconstructive surgery: Evaluating the mechanical interaction between flap design and anisotropy.

Acta biomaterialia·2026
Same journal

Diabetes alters protein corona to reprogram wear particle-cell interaction.

Acta biomaterialia·2026
See all related articles

Triple-helical peptides (THPs) mimic collagen to enhance cell interactions with biomaterials. This strategy improves cell adhesion and function, offering significant potential for regenerative medicine applications in tissue repair.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Cell Biology

Background:

  • Biomaterials often lack biological cues necessary for cell interaction.
  • Functionalization of biomaterials aims to mimic the native cellular microenvironment, particularly collagen.
  • Triple-helical peptides (THPs) are collagen-mimicking molecules that can provide specific biological signals.

Purpose of the Study:

  • To review the characteristics of THPs and their impact on cell behavior when incorporated into biomaterials.
  • To highlight the potential of THPs as biomimetic tools in regenerative medicine.
  • To guide researchers in selecting appropriate functionalization strategies for biomaterials.

Main Methods:

  • Review of literature on THP functionalization of biomaterials.
Keywords:
Biomaterial functionalizationCell-collagen interactionsCollagen triple helixCollagen-mimetic peptideTissue repair

More Related Videos

Culturing Mammalian Cells in Three-dimensional Peptide Scaffolds
07:52

Culturing Mammalian Cells in Three-dimensional Peptide Scaffolds

Published on: June 13, 2018

10.3K
A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.5K

Related Experiment Videos

Last Updated: Sep 20, 2025

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids
10:23

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids

Published on: May 3, 2024

1.0K
Culturing Mammalian Cells in Three-dimensional Peptide Scaffolds
07:52

Culturing Mammalian Cells in Three-dimensional Peptide Scaffolds

Published on: June 13, 2018

10.3K
A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

9.5K
  • Analysis of studies demonstrating THP effects on cell adhesion, differentiation, and function.
  • Discussion of THP applications in various tissue engineering contexts.

    • Main Results:

    • THPs, particularly those with the GFOGER motif, effectively promote cell adhesion by interacting with collagen-binding integrins.
    • Functionalization with THPs has shown significant improvements in cell function for applications like tissue repair, vascular grafts, and wound healing.
    • THPs offer a biomimetic approach to guide cell responses on inert biomaterials.

    Conclusions:

    • THPs are potent tools for enhancing cell-biomaterial interactions in tissue engineering.
    • The use of THPs can significantly improve outcomes in regenerative medicine applications.
    • Further exploitation of THPs is recommended to overcome limitations in current biomaterial functionalization strategies.