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Updated: Sep 20, 2025

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Ultrasensitive Detection of Biomarkers in a Color-Switchable Microcavity-Reactor Laser.

Ran Li1, Zongpeng Song1, Haiou Zhu1

  • 1College of New Materials and New Energies, Shenzhen Technology University, Shenzhen, 518118, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|June 8, 2022
PubMed
Summary

This study introduces a novel color-switchable lasing method for ultrasensitive biomarker detection. This technique significantly lowers the limit of detection (LOD) for early disease diagnosis.

Keywords:
biomarkerscolor-switchable microlasersultrasensitive detectionvisual distinguishability

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Early disease detection relies on sensitive biomarker identification.
  • Current in vitro methods are sensitive but not in vivo compatible.
  • In vivo fluorescence detection has limitations in sensitivity and limit of detection (LOD).

Purpose of the Study:

  • To develop a fundamentally new strategy for ultrasensitive biomarker detection.
  • To demonstrate a color-switchable lasing approach with cavity-enhanced reduction of LOD.
  • To enable in vivo compatible and highly sensitive disease diagnostics.

Main Methods:

  • Utilized a dye-embedded, in vivo compatible polystyrene-sphere cavity as a laser cavity and bio-reactor.
  • Biomarkers interact with dye molecules within the sphere, altering lasing signals.
  • Achieved cavity-enhanced emission and lasing, enabling single-biomarker molecule detection.

Main Results:

  • Demonstrated ultrasensitive detection with a quantitative LOD of 1.4 × 10-16 mg ml-1.
  • Achieved a qualitative LOD as low as 10-17 mg ml-1, surpassing fluorescence and plasmonic methods.
  • Observed improved visual distinguishability through color changes in lasing signals.

Conclusions:

  • The developed color-switchable lasing strategy offers unprecedented sensitivity for biomarker detection.
  • The polystyrene-sphere cavity acts as an effective in vivo bio-reactor and laser cavity.
  • This method holds potential for integration into multiplexing detection assay biochips for advanced diagnostics.