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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Transcriptomic analysis reveals pathophysiological relationship between chronic obstructive pulmonary disease (COPD)
Shuqin Liu1, Yun Fu2, Dirk Ziebolz3
1Department of Stomatology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Aiguo Road No. 152, Nanchang, 330006, Jiangxi Province, China.
BMC Medical Genomics
|June 8, 2022
Summary
This study identified three key genes (EPB41L4A-AS1, INSR, R3HDM1) that may link periodontitis and chronic obstructive pulmonary disease (COPD). These findings suggest a shared biological basis and potential therapeutic targets for both conditions.
Area of Science:
- Genomics and Bioinformatics
- Immunology
- Pulmonology
Background:
- Periodontitis and chronic obstructive pulmonary disease (COPD) are distinct inflammatory conditions.
- Emerging evidence suggests potential shared etiological factors and pathophysiological pathways between periodontitis and COPD.
- Understanding the molecular crosstalk between these diseases is crucial for developing integrated treatment strategies.
Purpose of the Study:
- To identify overlapping differentially expressed genes (DEGs) between chronic periodontitis (CP) and COPD.
- To investigate the immune cell infiltration patterns associated with both CP and COPD.
- To uncover potential crosstalk genes and their correlation with immune cells in CP and COPD.
Main Methods:
- Downloaded and analyzed gene expression datasets for CP (GSE156993) and COPD (GSE42057, GSE94916).
- Identified overlapping DEGs and performed functional pathway enrichment analysis.
- Utilized the xCell method for immune cell infiltration analysis and Recursive Feature Elimination (RFE) for gene feature selection.
- Applied Receiver-operating characteristic (ROC) curves and Pearson correlation analysis to validate findings.
Main Results:
- Identified 22 overlapping DEGs between CP and COPD out of 904 DEGs in COPD and 763 DEGs in CP.
- Eight immune cell pairs showed significant correlation with both diseases.
- RFE identified EPB41L4A-AS1, INSR, and R3HDM1 as key crosstalk genes.
- INSR and R3HDM1 demonstrated significant correlations with specific cell types (Hepatocytes and Th1 cells, respectively) in both CP and COPD.
Conclusions:
- EPB41L4A-AS1, INSR, and R3HDM1 are proposed as potential crosstalk genes linking periodontitis and COPD.
- The positive correlation of INSR with Hepatocytes and R3HDM1 with Th1 cells in both diseases supports a shared pathophysiological basis.
- These findings highlight a potential molecular connection, suggesting common therapeutic targets for periodontitis and COPD.
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