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Published on: December 19, 2020
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SARS-CoV-2 and probable lung cancer risk
Sajad Khiali1, Afra Rezagholizadeh1, Taher Entezari-Maleki1,2
1Department of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Bioimpacts : BI
|June 9, 2022
Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may promote lung cancer by acting as an oncovirus. This review explores three potential oncogenic mechanisms linked to coronavirus disease 2019 (COVID-19) and lung cancer development.
Area of Science:
- * Oncology
- * Virology
- * Respiratory Medicine
Background:
- * The global COVID-19 pandemic caused by SARS-CoV-2 presents significant mortality and morbidity.
- * Long-term complications and immunity following COVID-19 remain incompletely understood.
- * SARS-CoV-2 shares pathophysiological similarities with oncoviruses in lung tissue.
Purpose of the Study:
- * To explore the potential oncogenic mechanisms of SARS-CoV-2.
- * To investigate the association between SARS-CoV-2 infection and lung cancer development.
- * To summarize three proposed pathways through which SARS-CoV-2 may contribute to lung cancer.
Main Methods:
- * Review of existing literature on SARS-CoV-2 pathophysiology.
- * Analysis of potential oncogenic mechanisms based on viral characteristics.
- * Synthesis of evidence linking viral infection to cancer development.
Main Results:
- * SARS-CoV-2 exhibits characteristics suggesting oncoviral activity in the lungs.
- * Three distinct oncogenic mechanisms are proposed for SARS-CoV-2.
- * These mechanisms may increase the risk of lung cancer post-infection.
Conclusions:
- * SARS-CoV-2 may play a role in lung cancer development through oncogenic mechanisms.
- * Further research is crucial to elucidate the long-term oncological risks of COVID-19.
- * Understanding these mechanisms can inform future prevention and treatment strategies.
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