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Association Between Metformin and Abdominal Aortic Aneurysm: A Meta-Analysis
Wenqiang Niu1, Juan Shao2, Benxiang Yu1
1Department of Vascular Surgery, Yantai Yuhuangding Hospital, Yantai, China.
Frontiers in Cardiovascular Medicine
|June 9, 2022
Summary
Metformin may limit abdominal aortic aneurysm (AAA) expansion and reduce AAA-related mortality. Further research is needed to confirm these findings for AAA treatment.
Area of Science:
- Cardiovascular Research
- Pharmacology
- Medical Statistics
Background:
- Abdominal aortic aneurysm (AAA) is a life-threatening condition with limited treatment options.
- Metformin, a common diabetes drug, has shown potential in preclinical studies for cardiovascular benefits.
- A systematic review and meta-analysis were conducted to evaluate the association between metformin and AAA.
Approach:
- A comprehensive literature search was performed across major databases (PubMed, Embase, Cochrane Library, Ovid) up to February 2022.
- Seven articles comprising 10 cohort studies with 85,050 patients were included after screening.
- Meta-analysis was conducted using Stata 16.0 and RevMan 5.3 software.
Key Points:
- Metformin use was associated with a statistically significant limitation in AAA expansion (MD = -0.72, P < 0.00001).
- Metformin was linked to a reduced risk of AAA repair or rupture-related mortality (OR = 0.80, P = 0.02).
- The observed differences were statistically significant (P < 0.05).
Conclusions:
- Metformin demonstrates potential in limiting AAA expansion and reducing associated mortality.
- These findings suggest a possible therapeutic role for metformin in managing AAA.
- Further biological experiments and clinical trials are warranted to validate these results.
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