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Updated: Sep 20, 2025

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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Tracking mutation and drug-driven alterations of oncokinase conformations

Andreas Feichtner1, Valentina Kugler1, Selina Schwaighofer1

  • 1Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.

Memo
|June 9, 2022
PubMed
Summary

This study introduces a novel kinase conformation (KinCon) biosensor for live-cell analysis of kinase activity. This tool aids in selecting effective cancer drugs tailored to specific patient mutations.

Keywords:
BRAF inhibitorCancer drug efficacyCell based reporter assayKinase biosensorMEK inhibitorPersonalized therapy

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