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Systemic Multimorbidity Clusters in People with Periodontitis.

H Larvin1, J Kang2, V R Aggarwal1

  • 1School of Dentistry, University of Leeds, Leeds, UK.

Journal of Dental Research
|June 9, 2022
PubMed
Summary
This summary is machine-generated.

People with periodontitis often have multiple health conditions. Hypertension and obesity commonly co-occur, while diabetes impacts severe periodontitis clusters. Factors like ethnicity and smoking also play a role.

Keywords:
big dataepidemiological factorshypergraphnetwork analysisoral healthperiodontal diseases

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Area of Science:

  • Oral Health
  • Network Analysis
  • Public Health

Background:

  • Periodontitis is a common oral infection linked to various systemic diseases.
  • Understanding multimorbidity patterns in periodontitis is crucial for comprehensive patient care.
  • Artificial intelligence offers novel approaches to analyze complex health data.

Purpose of the Study:

  • To identify systemic multimorbidity clusters in individuals with periodontitis using AI.
  • To investigate the influence of periodontitis severity on these clusters.
  • To explore associated factors impacting multimorbidity patterns.

Main Methods:

  • Utilized cross-sectional data from 3,736 participants (National Health and Nutrition Examination Survey, 2009-2014).
  • Applied hypergraph network analysis with eigenvector centralities to identify disease clusters.
  • Stratified analysis by clinical attachment loss (CAL) quartiles to assess periodontitis severity impact.

Main Results:

  • Identified 106 unique systemic multimorbidity clusters.
  • Hypertension, arthritis, and obesity were the most prevalent diseases.
  • "Hypertension, obesity" emerged as the largest multimorbidity cluster.
  • Diabetes centrality increased with higher CAL quartiles, indicating greater influence in severe periodontitis.

Conclusions:

  • Revealed common systemic multimorbidity clusters associated with periodontitis.
  • Highlighted the frequent co-occurrence of hypertension and obesity in this population.
  • Emphasized the heightened influence of diabetes in severe periodontitis and the role of factors like ethnicity, deprivation, and smoking.