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The effect of amitriptyline on the central nervous system penetration of methotrexate
Cancer Drug Delivery
|January 1, 1986
Abstract:
The reported ability of amitriptyline to enhance the penetration of diffusion limited substances across the blood brain barrier was investigated. The CSF:plasma ratio of methotrexate in primates was not significantly altered by amitriptyline pretreatment. Nor was methotrexate plasma clearance altered.
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