Mechanosensitive Steroid Hormone Signaling and Cell Fate

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Jason J Northey1,2, Valerie M Weaver1,2,3,4,5

  • 1Department of Surgery, University of California, San Francisco, CA 94143, USA.

Endocrinology
|June 9, 2022
PubMed

Insights

Mechanical forces and steroid hormones coordinate cell fate in development and tissue homeostasis. Their signaling pathways intersect, influencing cell fate during development and cancer progression.

Area of Science:

  • Cell biology
  • Developmental biology
  • Endocrinology

Background:

  • Mechanical forces and steroid hormones are crucial for tissue development and homeostasis.
  • Disrupted steroid hormone signaling is linked to hormone-sensitive tumors.
  • Mechanical force alterations can promote tumor initiation and metastasis.

Purpose of the Study:

  • To explore the intersection of mechanical and steroid hormone signaling in cell fate determination.
  • To discuss potential mechanosensitive steroid hormone pathways and their effectors.

Main Methods:

  • Literature review of recent evidence on mechanical and steroid hormone signaling.
  • Discussion of molecular effectors and signaling pathways.

Main Results:

  • Mechanical forces and steroid hormones collaborate to regulate cell fate.
  • These signaling pathways intersect during development and tumor progression.
  • Potential mechanosensitive pathways mediating these interactions are identified.

Conclusions:

  • The interplay between mechanical forces and steroid hormones is critical for cell fate regulation.
  • Understanding these intersections can inform therapeutic strategies for hormone-related diseases and cancer.
Keywords:
cell fatemechanosensitivemechanotransductionreproductive cancerssteroid hormonestissue mechanics

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