Renal oncocytoma. A cytogenetic and morphologic study

A detailed G-banded chromosome analysis was performed in primary cell cultures obtained from two renal oncocytomas. Both tumors were characterised by clonal chromosome aberrations. One had a stemline karyotype 45,X,-X,rcp(8;19),der(13)t(X;13) and several sidelines with variant additional aberrations. The chromosome analysis of the other neoplasm revealed a pseudodiploid stemline 46,XY,del(1q),der(13)t(1;13) and cells with normal karyotype; both types of cells showed several telomeric associations of chromosomes, formed mostly by smaller chromosomes. The chromosome pattern of oncocytomas is discussed in comparison with the cytogenetics of renal cell carcinomas.