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Functional Two-Way Crosstalk Between Brain and Lung: The Brain-Lung Axis
Chunyi Li1, Wenli Chen2, Feng Lin1
1Department of Cerebrovascular Disease, Sun Yat-Sen University, The Fifth Affiliated Hospital, Zhuhai, 519000, Guangdong, People's Republic of China.
Cellular and Molecular Neurobiology
|June 9, 2022
Summary
The brain-lung axis describes bidirectional communication between the brain and lungs. This connection influences physiological states and is linked to various lung and central nervous system (CNS) diseases.
Area of Science:
- Neuroscience
- Pulmonology
- Immunology
- Microbiology
Background:
- The brain exhibits extensive connections with numerous organs.
- A bidirectional communication pathway, the brain-gut axis, between the central nervous system (CNS) and the intestinal tract is established.
- Evidence suggests communication pathways exist between the brain and lungs, but a defined brain-lung axis remains uncharacterized.
Purpose of the Study:
- To propose and define the existence of a brain-lung axis.
- To elucidate the pathways involved in the communication between the brain and lungs.
- To explore the implications of this axis in physiological regulation and disease pathogenesis.
Main Methods:
- Hypothesis formulation based on existing literature.
- Review of neuroanatomical, endocrine, immune, metabolic, microbial, and gaseous signaling pathways.
- Analysis of the role of bidirectional communication in disease.
Main Results:
- A hypothesis for the brain-lung axis is proposed, involving communication via neuroanatomical, endocrine, immune, metabolic, microbial, and gas pathways.
- This bidirectional communication influences physiological homeostasis.
- The brain-lung axis is implicated in the pathogenesis of both lung diseases and CNS disorders.
Conclusions:
- The brain-lung axis represents a significant communication network between the central nervous system and the lungs.
- Understanding this axis is crucial for comprehending disease mechanisms.
- The brain-lung axis offers potential therapeutic targets for treating related diseases.
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