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NUCB2: roles in physiology and pathology.
Qing Zhou1,2, Ying Liu1,2, Ranran Feng1,2
1Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Journal of Physiology and Biochemistry
|June 9, 2022
Summary
Nucleobindin2 (NUCB2) is involved in energy balance and physiological regulation. This review explores NUCB2
Area of Science:
- Biochemistry
- Molecular Biology
- Physiology
Background:
- Nucleobindin2 (NUCB2) is a protein family member identified in the hypothalamus.
- NUCB2 is implicated in regulating diet and energy homeostasis.
- Its presence in tissues like the stomach and islets highlights its physiological importance.
Purpose of the Study:
- To comprehensively review the expression and functions of NUCB2.
- To elucidate the role of NUCB2 in both physiological and pathological processes.
- To explore the underlying mechanisms of NUCB2's involvement in tumorigenesis.
Main Methods:
- Literature review of existing studies on NUCB2.
- Analysis of NUCB2's expression patterns in normal and cancerous tissues.
- Investigation of NUCB2's impact on various cellular processes like proliferation, apoptosis, and metastasis.
Main Results:
- NUCB2 plays a role in regulating physiological functions.
- NUCB2 is involved in tumorigenesis by influencing multiple signaling pathways.
- Evidence suggests NUCB2 can either promote or inhibit tumor cell proliferation, apoptosis, autophagy, metastasis, and invasion.
Conclusions:
- NUCB2 is a key regulator in physiological functions and disease pathology.
- NUCB2's dual role in cancer progression warrants further investigation.
- Future research should focus on NUCB2's therapeutic potential and detailed mechanisms in tumorigenesis.
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