Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Profiling Immune-Independent Response to Immune Checkpoint Inhibitors on Stem Cell-Derived Cardiomyocytes, Organoids, and Mouse Models.

Circulation·2026
Same author

Multiscale profiling of tyrosine kinase inhibitor cardiotoxicity reveals mechanosensitive ion channel PIEZO1 as cardioprotective.

Science translational medicine·2025
Same author

CCL2-mediated endothelial injury drives cardiac dysfunction in long COVID.

Nature cardiovascular research·2024
Same author

Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles.

Nature materials·2023
Same author

Ventricular tachyarrhythmia treatment and prevention by subthreshold stimulation with stretchable epicardial multichannel electrode array.

Science advances·2023
Same author

Recreating the heart's helical structure-function relationship with focused rotary jet spinning.

Science (New York, N.Y.)·2022

Related Experiment Video

Updated: Sep 20, 2025

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells
10:37

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

6.8K

Cellular and Engineered Organoids for Cardiovascular Models.

Dilip Thomas1,2, Suji Choi3, Christina Alamana1,2

  • 1Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA (D.T., C.A., J.C.W.).

Circulation Research
|June 9, 2022
PubMed
Summary
This summary is machine-generated.

Advanced in vitro cardiac tissue models, using patient-specific stem cells and physiological cues, improve cardiovascular disorder research. These engineered heart tissues and microphysiological systems offer robust phenotyping for disease modeling and drug screening.

Keywords:
cardiovascular diseaseheartorganoidsphenotypepluripotent stem cellstissue engineering

More Related Videos

Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices
09:35

Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices

Published on: June 16, 2020

10.1K
Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement
04:41

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement

Published on: December 13, 2024

2.1K

Related Experiment Videos

Last Updated: Sep 20, 2025

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells
10:37

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

6.8K
Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices
09:35

Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices

Published on: June 16, 2020

10.1K
Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement
04:41

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement

Published on: December 13, 2024

2.1K

Area of Science:

  • Biomedical Engineering
  • Stem Cell Biology
  • Cardiovascular Research

Background:

  • In vitro cardiac tissue models are crucial for understanding cardiovascular disorders.
  • Patient-specific induced pluripotent stem cells enhance disease modeling capabilities.
  • Physiological cues are essential for achieving mature, functional cardiac models.

Purpose of the Study:

  • To review advances in directed stem cell differentiation for cardiovascular cell types.
  • To highlight progress in various cardiovascular models (organoids, microtissues, engineered heart tissues, microphysiological systems).
  • To discuss model selection criteria, limitations, and future directions.

Main Methods:

  • Review of directed stem cell differentiation techniques.
  • Analysis of current cardiovascular model development.
  • Discussion of physiological cue integration (biochemical, biophysical, electromechanical).

Main Results:

  • Directed differentiation enables diverse cardiovascular cell type generation for customized models.
  • Recent progress includes cardiac organoids, microtissues, engineered heart tissues, and microphysiological systems.
  • Integration of physiological cues enhances tissue maturity and phenotyping robustness.

Conclusions:

  • Cardiac tissue models are advancing with stem cell technology and physiological integration.
  • Careful selection based on the context of use is vital for model utility.
  • Addressing current limitations will drive future innovations in cardiovascular research models.