Related Experiment Video
Updated: Aug 4, 2026

The Forced Swim Test as a Model of Depressive-like Behavior
Published on: March 2, 2015
Depression: the evolution of modern paradigms and concepts
Abstract:
We have presently three paradigms of depression: the psychoanalytic, the cognitive-behavioral, and the biological. The biological has so far produced the most effective treatment, but this theoretical structure is still the least cohesive; it is also less connected with its associated therapies than the two other paradigms. The search for unifying concepts and for indicators that may point to more specific therapeutic approaches to depression, goes on. It is an exciting search, but we must guard against the danger of losing contact between the rapidly progressing neurosciences and clinical research-the contact that should remain a precious "therapeutic alliance."
Related Concept Videos
Depression: Overview
Evolutionary Psychology
Theoretical Approaches to Psychological Disorder
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
Depressive Disorders: MDD and Dysthymia
Cognitive Therapy
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

