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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: Sep 20, 2025

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Quantitative MRI in Multiple Sclerosis: From Theory to Application.

M Tranfa¹, G Pontillo^2,3, M Petracca⁴

¹From the Departments of Advanced Biomedical Sciences (M.T., G. Pontillo, A.B., E.T., S.C.).

AJNR. American Journal of Neuroradiology

|June 9, 2022

Summary

This summary is machine-generated.

Quantitative MR imaging offers valuable insights into brain microstructure changes in Multiple Sclerosis (MS). This review details techniques like relaxometry and quantitative susceptibility mapping for assessing myelin and iron content in MS patients.

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Area of Science:

Neuroimaging
Biophysics
Neurology

Background:

Quantitative MR imaging provides insights into brain microstructure.
Multiple Sclerosis (MS) involves inflammatory and neurodegenerative processes affecting myelin and iron content.
Understanding these changes is crucial for MS pathophysiology.

Purpose of the Study:

To review the physics and neurobiological correlates of quantitative MR imaging techniques.
To summarize the applications and findings of quantitative MR imaging in MS.
To analyze changes in both gray and white matter in MS patients.

Main Methods:

Review of quantitative MR imaging physics, including relaxometry and quantitative susceptibility mapping.
Analysis of neurobiological underpinnings of quantitative MR imaging findings.
Synthesis of published data on quantitative MR imaging in Multiple Sclerosis.

Main Results:

Quantitative MR imaging techniques like relaxometry and quantitative susceptibility mapping are sensitive to myelin and iron content.
These techniques reveal microstructural changes in both normal-appearing and damaged brain parenchyma in MS.
Findings are reported for both gray and white matter compartments in MS patients.

Conclusions:

Quantitative MR imaging is an invaluable tool for studying MS pathophysiology.
It allows for detailed assessment of myelin and iron alterations in MS.
Further research can leverage these techniques for improved MS diagnosis and monitoring.