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Summary
This study evaluated cefoperazone susceptibility in over one million aerobic bacterial isolates across multiple countries. Cefoperazone demonstrated high in vitro activity against key pathogens, with minimal variation observed between geographic locations.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Antibiotic resistance is a growing global health concern.
- Cefoperazone is a third-generation cephalosporin antibiotic.
- Monitoring antimicrobial susceptibility is crucial for effective treatment.
Purpose of the Study:
- To assess the in vitro susceptibility of a large number of clinical aerobic bacterial isolates to cefoperazone.
- To compare cefoperazone susceptibility patterns across different countries and body sites.
Main Methods:
- Disk diffusion method was used to evaluate susceptibility.
- Over one million aerobic bacterial isolates were analyzed.
- Data were collected from 369 hospitals across Japan, the United States, Canada, France, Austria, and Hungary.
Main Results:
- High susceptibility rates to cefoperazone were observed for key pathogens, including Escherichia coli (91-98%), Klebsiella pneumoniae (90-95%), and Proteus mirabilis (91-97%).
- Susceptibility varied slightly for Pseudomonas aeruginosa (73-91%), Enterobacter cloacae (73-92%), and Staphylococcus aureus (74-92%).
- Bacterial susceptibility to cefoperazone showed minimal variation among the participating countries and between different body sites, including the urinary tract.
Conclusions:
- Cefoperazone exhibits significant in vitro activity against a broad spectrum of aerobic bacterial pathogens.
- Geographic location and body site had a limited impact on cefoperazone susceptibility patterns.
- These findings support the continued utility of cefoperazone in treating bacterial infections.