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Updated: Jul 27, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
10:04

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[Research Progress of Non-coding RNAs in the Regulation of Multiple Myeloma Bone Disease--Review]

Su-Mei Li1, Man-Ya Yu1, Xing Cui2

  • 1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250011, Shandong Province, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|June 10, 2022
PubMed

Insights

Non-coding RNAs are key regulators of bone remodeling in multiple myeloma bone disease. Targeting these molecules offers a promising new avenue for treating persistent bone lesions in patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Bone Biology

Background:

  • Multiple myeloma bone disease is a frequent complication that worsens prognosis and quality of life.
  • This bone disease involves an imbalance in bone remodeling, contributing to myeloma progression.
  • Existing treatments often fail to heal bone lesions, even in remission, due to suppressed osteoblast activity.

Purpose of the Study:

  • To review recent advances in understanding non-coding RNAs in multiple myeloma bone disease.
  • To highlight the role of non-coding RNAs in regulating gene expression and signaling pathways involved in bone remodeling.
  • To explore non-coding RNAs as potential therapeutic targets for multiple myeloma bone disease.

Main Methods:

  • Literature review of recent studies on non-coding RNAs and multiple myeloma bone disease.
  • Analysis of research on non-coding RNA regulation of gene expression in bone remodeling.
  • Synthesis of findings on the role of non-coding RNAs in osteoblast activity and bone healing.

Main Results:

  • Non-coding RNAs significantly influence the imbalance of bone remodeling in multiple myeloma.
  • These molecules regulate critical genes and signaling pathways affecting bone metabolism.
  • Non-coding RNAs are implicated in the failure of bone lesions to heal in myeloma patients.

Conclusions:

  • Non-coding RNAs are crucial players in the pathogenesis of multiple myeloma bone disease.
  • Dysregulation of non-coding RNAs contributes to impaired bone healing and osteoblast suppression.
  • Non-coding RNAs represent a novel and promising field for therapeutic intervention in multiple myeloma bone disease.
Keywords:
bone diseasemultiple myelomanon-coding RNAosteoblastosteoclast

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