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Related Experiment Videos

A serial-section study of perforated synapses in rat neocortex.

R K Calverley, D G Jones

    Cell and Tissue Research
    |March 1, 1987
    PubMed
    Summary

    Perforated synapses in rat parietal cortex show distinct morphology, with 92% being axospinous with asymmetrical contacts. These synapses feature larger postsynaptic densities (PSDs) and irregular shapes, aiding in classification.

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    Area of Science:

    • Neuroscience
    • Cell Biology
    • Synaptic Plasticity

    Background:

    • Perforated synapses are specialized synaptic structures found in the brain.
    • Understanding their morphology is crucial for comprehending synaptic function and plasticity.
    • Previous studies have provided limited detailed morphological data on perforated synapses in specific cortical regions.

    Purpose of the Study:

    • To investigate the detailed morphology of perforated synapses in the molecular layer of the rat parietal cortex.
    • To characterize the structural features, including shape, curvature, and postsynaptic density (PSD) dimensions.
    • To establish criteria for identifying perforated synapses from single sections.

    Main Methods:

    • Electron microscopy was used to examine perforated synapses in 28-day-old rats.
    • Serial sectioning and reconstruction were employed for detailed analysis of synaptic structures.
    • Morphometric analysis was performed on perforated and non-perforated synapses.

    Main Results:

    • 92% of analyzed perforated synapses were axospinous with asymmetrical contacts.
    • Perforated synapses exhibited significantly larger PSDs (mean 581 nm) compared to non-perforated synapses (mean 233 nm).
    • A high prevalence (up to 95%) of negative curvature was observed in perforated synapses, with irregular shapes and occasional coated vesicles at perforation sites.

    Conclusions:

    • Perforated synapses in the rat parietal cortex possess unique morphological characteristics, including specific contact types and larger PSDs.
    • The observed morphological features, such as negative curvature and irregular PSDs, may be functionally significant.
    • The study provides a basis for classifying perforated synapses and identifying them in single sections.

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