Multipotential differentiation of human Y-79 retinoblastoma cells in attachment culture

The human Y-79 retinoblastoma cell line has been studied in attachment culture. Evidence is presented of its capability to differentiate partially into cells with characteristics of photoreceptors, conventional neurons, glia and pigment epithelial cells as influenced by appropriate combinations of substrata and differentiating agents. We conclude that retinoblastoma could originate from a primitive neuroectodermal cell of multi-potential character.