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Novel Functions of Integrins as Receptors of CD154: Their Role in Inflammation and Apoptosis

Ghada S Hassan1, Suzanne Salti1, Walid Mourad1

  • 1Laboratoire d'Immunologie Cellulaire et Moléculaire, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM), 900 rue Saint-Denis, Tour Viger, Montréal, QC H2X 0A9, Canada.

Cells
|June 10, 2022
PubMed

Insights

Integrins, cell surface receptors, bind to CD154 (CD40 ligand), a key inflammatory mediator. This interaction influences immune responses, cell adhesion, and apoptosis, impacting diseases like cancer and autoimmunity.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Medicine

Background:

  • CD154 (CD40 ligand) is a critical inflammatory mediator.
  • Integrins are cell surface receptors involved in cell adhesion and signaling.
  • Previous research identified specific integrin-CD154 interactions, hinting at broader roles.

Purpose of the Study:

  • To review the emerging role of integrins as receptors for CD154.
  • To explore the implications of these interactions in inflammatory and apoptotic processes.
  • To highlight novel CD154-integrin dyads and their biological significance.

Main Methods:

  • Literature review of studies investigating CD154-integrin interactions.
  • Analysis of data on integrin expression and function in various cell types.
  • Synthesis of findings related to pro-inflammatory and apoptotic signaling pathways.

Main Results:

  • Integrins αIIbβ3, αMβ2, α5β1, αvβ3, and α4β1 have been identified as CD154 receptors.
  • CD154-integrin interactions mediate platelet aggregation, myeloid cell activation, and T cell responses.
  • These interactions contribute to pro-inflammatory mediator release and apoptosis resistance, impacting disease pathogenesis.

Conclusions:

  • Integrins represent a novel class of CD154 receptors.
  • CD154-integrin signaling plays a significant role in inflammation and cell survival.
  • Further research into these interactions may reveal new therapeutic targets for inflammatory and malignant diseases.

Keywords:
CD154active/inactive conformationapoptosisinflammationintegrinsmalignancyreceptor–ligand binding

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