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Updated: Sep 20, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
Cellular Senescence in Aging Lungs and Diseases
Arbi Aghali1, Maunick Lefin Koloko Ngassie2,3, Christina M Pabelick1,4
1Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Abstract:
Cellular senescence represents a state of irreversible cell cycle arrest occurring naturally or in response to exogenous stressors. Following the initial arrest, progressive phenotypic changes define conditions of cellular senescence. Understanding molecular mechanisms that drive senescence can help to recognize the importance of such pathways in lung health and disease. There is increasing interest in the role of cellular senescence in conditions such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) in the context of understanding pathophysiology and identification of novel therapies. Herein, we discuss the current knowledge of molecular mechanisms and mitochondrial dysfunction regulating different aspects of cellular senescence-related to chronic lung diseases to develop rational strategies for modulating the senescent cell phenotype in the lung for therapeutic benefit.
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