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Pilot Investigation on p75ICD Expression in Laryngeal Squamous Cell Carcinoma
Viviana Triaca1, Elena Fico2, Pamela Rosso2
1Institute of Biochemistry and Cell Biology, National Research Council (CNR), International Campus A. Buzzati-Traverso, Monterotondo Scalo, 00015 Rome, Italy.
Cancers
|June 10, 2022
Summary
The p75 Neurotrophin Receptor (p75NTR) and its cleavage product p75ICD show potential as oncogenic and metastatic markers in Laryngeal Squamous Cell Carcinoma (LSCC). Their expression correlates with tumor progression and cancer stem cell spread.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- p75 Neurotrophin Receptor (p75NTR) is implicated in cancer stem cell (CSC) properties like migration and chemo-resistance.
- Its role in Laryngeal Squamous Cell Carcinoma (LSCC) progression and metastasis requires further investigation.
Purpose of the Study:
- To evaluate p75NTR and its intracellular domain (p75ICD) as potential oncogenic and metastatic markers in LSCC.
- To analyze the clinical significance of p75NTR cleavage products in LSCC progression.
Main Methods:
- Analysis of full-length and cleaved p75NTR expression in primary LSCC tumors.
- Utilized molecular and histological techniques to detect p75NTR, p75ICD, and the CSC marker ABCG2.
- Examined co-localization of p75ICD and ABCG2 in tumor tissues.
Main Results:
- Observed regulated p75NTR cleavage during LSCC progression and invasion.
- p75ICD expression and localization appear linked to tumorigenesis and metastatic potential.
- Co-localization of p75ICD with ABCG2 suggests roles in tumor invasion and CSC spread.
Conclusions:
- p75NTR cleavage and p75ICD represent potential molecular signatures for LSCC.
- These findings may aid in LSCC diagnosis, prognosis, and personalized therapy development.
