Related Experiment Video

Updated: Sep 20, 2025

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
05:45

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

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Crosstalk of Epigenetic and Metabolic Signaling Underpinning Glioblastoma Pathogenesis

Mariam Markouli1, Dimitrios Strepkos1, Kostas A Papavassiliou1

  • 1Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Cancers
|June 10, 2022
PubMed

Insights

Epigenetic modifications regulate metabolic pathways in glioblastoma, influencing tumor growth. Targeting these epigenetic-metabolic interactions offers a promising therapeutic strategy for glioblastoma (GBM) progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Metabolic reprogramming is a hallmark of cancer, crucial for tumor development and progression.
  • Glioblastoma (GBM) exhibits significant metabolic alterations, driving its aggressive nature.
  • The interaction between epigenetics and metabolism in GBM is a critical area for therapeutic intervention.

Purpose of the Study:

  • To review the epigenetic mechanisms regulating metabolic pathways in glioblastoma.
  • To highlight the potential of targeting these epigenetic-metabolic pathways for glioblastoma therapy.

Main Methods:

  • Literature review of studies investigating epigenetic modifications and metabolic pathways in glioblastoma.
  • Analysis of how epigenetic regulators influence key metabolic routes like glycolysis, oxidative phosphorylation, and glutamine metabolism.

Main Results:

  • Epigenetic mechanisms can both activate and inhibit major metabolic pathways in glioblastoma cells.
  • These modifications contribute to the metabolic heterogeneity and plasticity of malignant cells.
  • Specific epigenetic regulators impact glycolysis, pentose phosphate pathway, lipid, and glutamine metabolism.

Conclusions:

  • Epigenetic modifications play a complex role in regulating glioblastoma cell metabolism.
  • Targeting the interplay between epigenetics and metabolism presents a viable strategy for glioblastoma treatment.
  • Understanding these interactions can lead to novel therapeutic approaches against tumor progression.
Keywords:
DNAKrebs cycleTCA cycleacetylationglioblastomagliomagluconeogenesisglutamineglycolysishistonesmethylationmicroRNAsoxidative phosphorylationpentose phosphate pathway

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