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Related Experiment Video

Updated: Sep 20, 2025

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Association between Incidental Pelvic Inflammation and Aggressive Prostate Cancer.

Dimple Chakravarty1, Parita Ratnani1, Li Huang2

  • 1Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Cancers
|June 10, 2022
PubMed
Summary

Pelvic inflammation significantly worsens prostate cancer (PCa) progression and aggressiveness. This inflammation is linked to adverse pathology and faster biochemical recurrence after surgery, indicating a more aggressive tumor phenotype.

Keywords:
AP (adverse pathology)BCR (biochemical recurrence)DDR (DNA damage and repair)ECE (extracapsular extension)EMT (epithelial-to-mesenchymal transition)EPE (extra prostatic extension)IL (interleukin)MRI (magnetic resonance imaging)PCa (prostate cancer)PI-RADS (prostate imaging reporting and data system version 2)PSA (prostate specific antigen)PSAD (prostate specific antigen density)RALP (robot-assisted laparoscopic prostatectomy)

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Area of Science:

  • Urology
  • Oncology
  • Pathology

Background:

  • The relationship between pelvic inflammation and prostate cancer (PCa) aggressiveness is not well understood.
  • Previous studies have not investigated the impact of pelvic inflammation on PCa biology and aggressive phenotypes.

Purpose of the Study:

  • To evaluate the role of pelvic inflammation in PCa aggressiveness.
  • To assess the association between pelvic inflammation and clinical outcomes in patients after radical prostatectomy (RP).

Main Methods:

  • Retrospective analysis of 2278 patients undergoing robot-assisted laparoscopic prostatectomy (RALP).
  • Association between pelvic inflammation and adverse pathology (AP) in 2085 patients.
  • Association between pelvic inflammation and biochemical recurrence (BCR) in 1997 patients.
  • Microarray, immunohistochemistry, and functional assays to study tumor transcriptome and inflammatory markers.
  • O-link analysis for blood inflammatory markers.

Main Results:

  • Pelvic inflammation is a significant predictor of AP (Gleason Grade Group > 2 and ≥ pT3 stage).
  • High pelvic inflammation, pT3 stage, and positive surgical margins significantly impacted BCR time.
  • PCa patients with high inflammation showed elevated pro-inflammatory cytokines and upregulated genes in epithelial-to-mesenchymal transition (EMT) and DNA damage response.
  • STAT and IL-6 signaling pathways were implicated in driving tumor progression from inflamed sites.

Conclusions:

  • Pelvic inflammation exacerbates prostate cancer progression.
  • Pelvic inflammation drives an aggressive PCa phenotype, impacting pathology and recurrence.
  • Targeting inflammatory pathways like STAT and IL-6 may offer therapeutic strategies.